Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts” in the Registration Statement (Form S-3) and related Prospectuses of Rigel Pharmaceuticals, Inc. for the registration up to $250,000,000 of its common stock, preferred stock, debt securities, warrants, units and rights, and to the incorporation by reference therein of our reports dated March 5, 2024, with respect to the financial statements of Rigel Pharmaceuticals, Inc., and the effectiveness of internal control over financial reporting of Rigel Pharmaceuticals, Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2023, filed with the Securities and Exchange Commission.