In February 2021, Rigel entered into a global exclusive license agreement with Lilly for Rigel’s RIPK1 inhibitor programs in all indications.
This collaboration includes the co-development and co-commercialization of Rigel’s R552, a receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor, for all indications including autoimmune and inflammatory diseases. Pursuant to the collaboration, Lilly will also lead all clinical development of brain penetrating RIPK1 inhibitors in central nervous system (CNS) diseases.
Rigel received an upfront payment and is eligible for development, regulatory, and commercial milestone payments, as well as tiered royalty payments on any future net sales of any products emerging from the collaboration.