Annual report pursuant to Section 13 and 15(d)

STATEMENT OF STOCKHOLDERS' EQUITY

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STATEMENT OF STOCKHOLDERS' EQUITY (USD $)
In Thousands, except Share data, unless otherwise specified
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Comprehensive Income (Loss)
Balance at Dec. 31, 2008 $ 104,165 $ 37 $ 605,509 $ 396 $ (501,777)  
Balance (in shares) at Dec. 31, 2008   36,646,397        
Increase (Decrease) in Stockholders' Equity            
Net income (loss) (111,547)       (111,547) (111,547)
Change in unrealized loss on available-for-sale securities (408)     (408)   (408)
Comprehensive income (loss) (111,955)         (111,955)
Issuance of common stock at $8.00 and $7.25 per share for cash, net of issuance costs for the year ended December 31, 2011 and 2009, respectively 101,460 15 101,445      
Issuance of common stock, net of issuance costs (in shares)   14,950,000        
Issuance of common stock upon exercise of options and participation in Purchase Plan 2,143   2,143      
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares)   359,743        
Stock-based compensation expense 13,438   13,438      
Warrant issued with lease amendment - 4 616   616      
Balance at Dec. 31, 2009 109,867 52 723,151 (12) (613,324)  
Balance (in shares) at Dec. 31, 2009   51,956,140        
Increase (Decrease) in Stockholders' Equity            
Net income (loss) 37,890       37,890 37,890
Change in unrealized loss on available-for-sale securities (26)     (26)   (26)
Comprehensive income (loss) 37,864         37,864
Issuance of common stock at $8.00 and $7.25 per share for cash, net of issuance costs for the year ended December 31, 2011 and 2009, respectively 0 0 0      
Issuance of common stock, net of issuance costs (in shares)   0        
Issuance of common stock upon exercise of options and participation in Purchase Plan 1,964   1,964      
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares)   315,044        
Stock-based compensation expense 16,436   16,436      
Warrant issued with lease amendment - 4 0   0      
Balance at Dec. 31, 2010 166,131 52 741,551 (38) (575,434)  
Balance (in shares) at Dec. 31, 2010   52,271,184        
Increase (Decrease) in Stockholders' Equity            
Net income (loss) (85,973)       (85,973) (85,973)
Change in unrealized loss on available-for-sale securities 44     44   44
Comprehensive income (loss) (85,929)         (85,929)
Issuance of common stock at $8.00 and $7.25 per share for cash, net of issuance costs for the year ended December 31, 2011 and 2009, respectively 140,505 19 140,486      
Issuance of common stock, net of issuance costs (in shares)   18,745,000        
Issuance of common stock upon exercise of options and participation in Purchase Plan 2,274   2,274      
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares)   362,868        
Stock-based compensation expense 13,168   13,168      
Warrant issued with lease amendment - 4 0   0      
Balance at Dec. 31, 2011 $ 236,149 $ 71 $ 897,479 $ 6 $ (661,407)  
Balance (in shares) at Dec. 31, 2011   71,379,052