| Schedule of stock-based compensation expense related to all of the entity's stock-based awards |
Total stock-based compensation expense related to all of our stock-based awards was as follows (in thousands):
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Year Ended December 31, |
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2012 |
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2011 |
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2010 |
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Research and development
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$ |
7,050 |
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$ |
9,277 |
|
$ |
9,025 |
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General and administrative
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|
5,567 |
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|
3,891 |
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|
7,411 |
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| |
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Total stock-based compensation expense
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$ |
12,617 |
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$ |
13,168 |
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$ |
16,436 |
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| Schedule of option activity under equity incentive plans |
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Shares
Available
For Grant |
|
Number of
Shares
Underlying
Options |
|
Weighted-
Average
Exercise Price |
|
Weighted-
Average
Remaining
Contractual Term
(in years) |
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Aggregate
Intrinsic
Value |
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Outstanding at January 1, 2010
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2,793,690 |
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7,914,869 |
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$ |
14.32 |
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| |
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Authorized for grant
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1,600,000 |
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— |
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Granted
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(1,957,020 |
) |
|
1,957,020 |
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$ |
8.60 |
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Exercised
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— |
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(86,459 |
) |
$ |
6.60 |
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Cancelled
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91,429 |
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(91,429 |
) |
$ |
16.04 |
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Outstanding at December 31, 2010
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2,528,099 |
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9,694,001 |
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$ |
13.22 |
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Authorized for grant
|
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4,350,000 |
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— |
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Granted
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(2,236,270 |
) |
|
2,236,270 |
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$ |
6.80 |
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Exercised
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— |
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(114,988 |
) |
$ |
6.67 |
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Cancelled
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65,924 |
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(65,924 |
) |
$ |
10.95 |
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Outstanding at December 31, 2011
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4,707,753 |
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11,749,359 |
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$ |
12.07 |
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| |
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Authorized for grant
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600,000 |
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— |
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Granted
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(2,149,266 |
) |
|
2,149,266 |
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$ |
8.13 |
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Exercised
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— |
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(254,149 |
) |
$ |
7.08 |
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Cancelled
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40,099 |
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(40,099 |
) |
$ |
19.60 |
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Outstanding at December 31, 2012
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3,198,586 |
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13,604,377 |
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$ |
11.52 |
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|
5.76 |
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$ |
16,768 |
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| |
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Vested and expected to vest at December 31, 2012
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13,569,092 |
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$ |
11.53 |
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Exercisable at December 31, 2012
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12,841,378 |
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$ |
11.75 |
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5.59 |
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$ |
16,729 |
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Exercisable at December 31, 2011
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10,982,934 |
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$ |
12.38 |
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Exercisable at December 31, 2010
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8,934,275 |
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$ |
13.34 |
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Weighted-average grant date fair value of options granted during 2012, 2011 and 2010 was $5.44, $4.63 and $6.14, respectively.
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| Schedule of stock options by exercise price |
Details of our stock options by exercise price are as follows as of December 31, 2012:
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Options Outstanding |
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Options Exercisable |
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Weighted-Average
Remaining
Contractual Life
(in years) |
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Exercise Price
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Number of
Shares Underlying
Options |
|
Weighted-Average
Exercise Price |
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Number of
Shares Underlying
Options |
|
Weighted-Average
Exercise Price |
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$6.48 - $6.49
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1,675,636 |
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6.24 |
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$ |
6.49 |
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1,671,713 |
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$ |
6.49 |
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$6.50 - $6.73
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2,406,410 |
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7.96 |
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6.72 |
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2,145,582 |
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6.70 |
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$6.74 - $8.15
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2,924,346 |
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7.74 |
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7.97 |
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2,494,317 |
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7.96 |
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$8.16 - $9.59
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1,267,156 |
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1.98 |
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8.44 |
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1,231,653 |
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8.44 |
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$9.60 - $11.23
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1,587,992 |
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6.25 |
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9.79 |
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1,555,276 |
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9.79 |
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$11.24 - $23.93
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1,960,633 |
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3.04 |
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17.36 |
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1,960,633 |
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17.36 |
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$23.94 - $26.45
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1,782,204 |
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4.36 |
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25.88 |
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1,782,204 |
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25.88 |
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$6.48 - $26.45
|
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13,604,377 |
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|
5.76 |
|
$ |
11.52 |
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12,841,378 |
|
$ |
11.75 |
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