Annual report pursuant to Section 13 and 15(d)

STATEMENT OF STOCKHOLDERS' EQUITY

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STATEMENT OF STOCKHOLDERS' EQUITY (USD $)
In Thousands, except Share data, unless otherwise specified
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Balance at Dec. 31, 2010 $ 166,131 $ 52 $ 741,551 $ (38) $ (575,434)
Balance (in shares) at Dec. 31, 2010   52,271,184      
Increase (Decrease) in Stockholders' Equity          
Net loss (85,973)       (85,973)
Change in unrealized gain (loss) on available-for-sale securities 44     44  
Issuance of common stock at $9.50 and $8.00 per share for cash, net of issuance costs for the year ended December 31, 2012 and 2011, respectively 140,505 19 140,486    
Issuance of common stock, net of issuance costs (in shares)   18,745,000      
Issuance of common stock upon exercise of options and participation in Purchase Plan 2,274   2,274    
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares)   362,868      
Stock compensation expense 13,168   13,168    
Balance at Dec. 31, 2011 236,149 71 897,479 6 (661,407)
Balance (in shares) at Dec. 31, 2011   71,379,052      
Increase (Decrease) in Stockholders' Equity          
Net loss (98,840)       (98,840)
Change in unrealized gain (loss) on available-for-sale securities 76     76  
Issuance of common stock at $9.50 and $8.00 per share for cash, net of issuance costs for the year ended December 31, 2012 and 2011, respectively 135,729 15 135,714    
Issuance of common stock, net of issuance costs (in shares)   15,237,750      
Issuance of common stock upon exercise of options and participation in Purchase Plan 3,365 1 3,364    
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares)   523,830      
Stock compensation expense 12,617   12,617    
Balance at Dec. 31, 2012 289,096 87 1,049,174 82 (760,247)
Balance (in shares) at Dec. 31, 2012   87,140,632      
Increase (Decrease) in Stockholders' Equity          
Net loss (89,027)       (89,027)
Change in unrealized gain (loss) on available-for-sale securities (35)     (35)  
Issuance of common stock upon exercise of options and participation in Purchase Plan 1,051 1 1,050    
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares)   383,717      
Stock compensation expense 7,166   7,166    
Balance at Dec. 31, 2013 $ 208,251 $ 88 $ 1,057,390 $ 47 $ (849,274)
Balance (in shares) at Dec. 31, 2013   87,524,349