Annual report pursuant to Section 13 and 15(d)

STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT)

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STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT) - USD ($)
$ in Thousands
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Loss
Accumulated Deficit
Total
Balance at Dec. 31, 2019 $ 168 $ 1,329,852 $ 23 $ (1,276,228) $ 53,815
Balance (in shares) at Dec. 31, 2019 167,987,850        
Increase (Decrease) in Stockholders' Equity          
Net loss       (29,744) (29,744)
Net unrealized loss on short-term investments     (27)   (27)
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 1 2,595     2,596
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 1,328,932        
Stock-based compensation expense   7,386     7,386
Balance at Dec. 31, 2020 $ 169 1,339,833 (4) (1,305,972) 34,026
Balance (in shares) at Dec. 31, 2020 169,316,782        
Increase (Decrease) in Stockholders' Equity          
Net loss       (17,914) (17,914)
Net unrealized loss on short-term investments     (98)   (98)
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 3 4,772     4,775
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 2,285,444        
Stock-based compensation expense   9,585     9,585
Balance at Dec. 31, 2021 $ 172 1,354,190 (102) (1,323,886) 30,374
Balance (in shares) at Dec. 31, 2021 171,602,226        
Increase (Decrease) in Stockholders' Equity          
Net loss       (58,573) (58,573)
Net unrealized loss on short-term investments     (51)   (51)
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 2 2,122     2,124
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 1,580,169        
Issuance of common stock upon vesting of restricted stock units (RSUs) (in shares) 216,250        
Stock-based compensation expense   12,510     12,510
Balance at Dec. 31, 2022 $ 174 $ 1,368,822 $ (153) $ (1,382,459) $ (13,616)
Balance (in shares) at Dec. 31, 2022 173,398,645