Annual report pursuant to Section 13 and 15(d)

INCOME TAXES (Tables)

v3.10.0.1
INCOME TAXES (Tables)
12 Months Ended
Dec. 31, 2018
INCOME TAXES  
Schedule of components of the entity's deferred tax assets

Significant components of our deferred tax assets are as follows (in thousands):

 

 

 

 

 

 

 

 

 

 

 

December 31,

 

 

    

2018

    

2017

 

Deferred tax assets

 

 

 

 

 

 

 

Net operating loss carryforwards

 

$

226,388

 

$

212,153

 

Orphan drug and research and development credits

 

 

55,276

 

 

51,744

 

Deferred compensation

 

 

7,155

 

 

12,261

 

Capitalized research and development expenses

 

 

424

 

 

4,690

 

Other, net

 

 

809

 

 

815

 

Total deferred tax assets

 

 

290,052

 

 

281,663

 

Valuation allowance

 

 

(290,052)

 

 

(281,663)

 

Net deferred tax assets

 

$

 —

 

$

 —

 

 

Schedule of reconciliation of the statutory federal income tax rate to the effective tax rate

 

 

 

 

 

 

 

 

 

 

Year Ended December 31,

 

 

    

2018

    

2017

    

2016

 

Federal statutory tax rate

 

(21.0)

%  

(34.0)

%  

(34.0)

%

Federal statutory rate reduction

 

 —

%  

160.2

%  

 —

%

State, Net of Federal Benefit

 

 —

%  

 —

%  

 —

%

Valuation allowance

 

16.3

%  

(126.5)

%  

35.0

%

Stock compensation

 

8.2

%  

5.7

%  

5.0

%

Orphan drug and research and development credits

 

(3.7)

%  

(3.6)

%  

(7.3)

%

Other, net

 

0.2

%  

(1.8)

%  

1.3

%  

Effective tax rate

 

0.0

%  

0.0

%  

0.0

%  

 

Schedule of activity related to the entity's gross unrecognized tax benefits

The following table summarizes the activity related to our gross unrecognized tax benefits (in thousands):

 

 

 

 

 

 

 

 

 

 

 

Year Ended December 31,

 

 

    

2018

    

2017

 

Balance at the beginning of the year

 

$

7,430

 

$

6,903

 

Increase related to prior year tax positions

 

 

 —

 

 

 —

 

Increase related to current year tax positions

 

 

419

 

 

527

 

Balance at the end of the year

 

$

7,849

 

$

7,430