Quarterly report pursuant to Section 13 or 15(d)

Stock-based Compensation (Details)

v2.4.1.9
Stock-based Compensation (Details) (USD $)
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Stock-based compensation expense related to stock-based awards    
Total stock-based compensation expense $ 2,054,000us-gaap_AllocatedShareBasedCompensationExpense $ 2,364,000us-gaap_AllocatedShareBasedCompensationExpense
Research and development    
Stock-based compensation expense related to stock-based awards    
Total stock-based compensation expense 1,160,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember
1,314,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember
General and administrative    
Stock-based compensation expense related to stock-based awards    
Total stock-based compensation expense $ 894,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_GeneralAndAdministrativeExpenseMember
$ 1,050,000us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_GeneralAndAdministrativeExpenseMember