Quarterly report pursuant to Section 13 or 15(d)

Stock-based Compensation (Details)

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Stock-based Compensation (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Sep. 30, 2015
Sep. 30, 2014
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense $ 1,815 $ 2,080 $ 5,778 $ 6,576
Research and development        
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense 966 1,151 3,182 3,654
General and administrative        
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense $ 849 $ 929 $ 2,596 $ 2,922