Quarterly report pursuant to Section 13 or 15(d)

Stock-based Compensation (Details)

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Stock-based Compensation (Details) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense $ 2,014,000 $ 1,909,000 $ 3,452,000 $ 3,963,000
Research and development        
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense 1,410,000 1,056,000 2,103,000 2,216,000
Incremental stock-based compensation expense 641,000   641,000  
General and administrative        
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense $ 604,000 $ 853,000 $ 1,349,000 $ 1,747,000