Annual report pursuant to Section 13 and 15(d)

STATEMENTS OF STOCKHOLDERS' EQUITY

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STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Total
Balance at Dec. 31, 2018 $ 167 $ 1,319,068 $ (24) $ (1,209,334) $ 109,877
Balance (in shares) at Dec. 31, 2018 167,171,505        
Increase (Decrease) in Stockholders' Equity          
Net loss       (66,894) (66,894)
Net change in unrealized gain (loss) on short-term investments     47   47
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 1 1,575     1,576
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 816,345        
Stock-based compensation expense   9,209     9,209
Balance at Dec. 31, 2019 $ 168 1,329,852 23 (1,276,228) 53,815
Balance (in shares) at Dec. 31, 2019 167,987,850        
Increase (Decrease) in Stockholders' Equity          
Net loss       (29,744) (29,744)
Net change in unrealized gain (loss) on short-term investments     (27)   (27)
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 1 2,595     2,596
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 1,328,932        
Stock-based compensation expense   7,386     7,386
Balance at Dec. 31, 2020 $ 169 1,339,833 (4) (1,305,972) 34,026
Balance (in shares) at Dec. 31, 2020 169,316,782        
Increase (Decrease) in Stockholders' Equity          
Net loss       (17,914) (17,914)
Net change in unrealized gain (loss) on short-term investments     (98)   (98)
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 3 4,772     4,775
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 2,285,444        
Stock-based compensation expense   9,585     9,585
Balance at Dec. 31, 2021 $ 172 $ 1,354,190 $ (102) $ (1,323,886) $ 30,374
Balance (in shares) at Dec. 31, 2021 171,602,226