Annual report pursuant to Section 13 and 15(d)

STATEMENTS OF OPERATIONS

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STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Total revenues $ 120,242,000 $ 149,236,000 $ 108,621,000
Costs and expenses:      
Cost of product sales 1,749,000 1,083,000 895,000
Research and development 60,272,000 65,237,000 60,101,000
Selling, general and administrative 112,451,000 91,891,000 76,598,000
Restructuring charges 1,320,000 3,521,000  
Total costs and expenses 175,792,000 161,732,000 137,594,000
Loss from operations (55,550,000) (12,496,000) (28,973,000)
Interest income 684,000 47,000 582,000
Interest expense (3,707,000) (4,860,000) (1,353,000)
Loss before income taxes (58,573,000) (17,309,000) (29,744,000)
Provision for income taxes   605,000  
Net loss $ (58,573,000) $ (17,914,000) $ (29,744,000)
Net loss per share, basic (in dollars per share) $ (0.34) $ (0.11) $ (0.18)
Net loss per share, diluted (in dollars per share) $ (0.34) $ (0.11) $ (0.18)
Weighted average shares used in computing net loss per share, basic (in shares) 172,406 170,492 168,754
Weighted average shares used in computing net loss per share, diluted (in shares) 172,406 170,492 168,754
Product sales, net      
Total revenues $ 76,718,000 $ 63,010,000 $ 61,696,000
Contract revenues from collaborations      
Total revenues 39,024,000 75,726,000 $ 46,925,000
Government contract      
Total revenues $ 4,500,000 $ 10,500,000