Quarterly report pursuant to Section 13 or 15(d)

Stock-based Compensation (Details)

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Stock-based Compensation (Details) (USD $)
In Thousands, unless otherwise specified
3 Months Ended 6 Months Ended
Jun. 30, 2014
Jun. 30, 2013
Jun. 30, 2014
Jun. 30, 2013
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense $ 2,132 $ 1,747 $ 4,496 $ 3,540
Research and Development Expense [Member]
       
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense 1,189 1,002 2,503 2,025
General and Administrative Expense [Member]
       
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense $ 943 $ 745 $ 1,993 $ 1,515