Annual report [Section 13 and 15(d), not S-K Item 405]

INCOME TAXES (Details)

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INCOME TAXES (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
INCOME TAXES      
Provision for income taxes $ 881    
Foreign taxes   $ 0 $ 0
Deferred tax assets      
Net operating loss carryforwards 222,744 229,967  
Orphan drug and research and development credits 62,314 62,457  
Capitalized research and development credits 19,604 21,017  
Deferred revenue 10,181 11,223  
Deferred compensation 11,701 10,365  
Other, net 2,751 3,898  
Deferred tax liabilities      
Others (61) (296)  
Total net deferred tax assets 329,234 338,631  
Less: valuation allowance (329,234) (338,631)  
Deferred tax assets, net of allowance  
Reconciliation of the statutory federal income tax rate to the effective tax rate      
Federal statutory tax rate (as a percent) (21.00%) (21.00%) (21.00%)
State, net of federal benefit (as a percent) 1.50% 0.10% 0.00%
Valuation allowance (as a percent) (30.30%) 13.90% 20.20%
Stock compensation (as a percent) 6.40% 5.30% 2.50%
Orphan drug and research and development credits (as a percent) 3.10% 0.20% (2.60%)
Foreign tax (as a percent) 3.20%    
Other, net (as a percent) (0.10%) 1.50% 1.00%
Effective tax rate (as a percent) 4.80% 0.00% 0.10%