Annual report pursuant to Section 13 and 15(d)

STATEMENTS OF OPERATIONS

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STATEMENTS OF OPERATIONS (USD $)
In Thousands, except Per Share data, unless otherwise specified
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
STATEMENTS OF OPERATIONS      
Contract revenues from collaborations $ 2,250 $ 4,750 $ 125,000
Costs and expenses:      
Research and development 78,778 69,350 64,392
General and administrative 22,849 21,768 25,291
Total costs and expenses 101,627 91,118 89,683
Income (loss) from operations (99,377) (86,368) 35,317
Interest income 537 420 303
Interest expense   (25) (91)
Other income     2,361
Net income (loss) $ (98,840) $ (85,973) $ 37,890
Net income (loss) per share:      
Basic (in dollars per share) $ (1.32) $ (1.36) $ 0.73
Diluted (in dollars per share) $ (1.32) $ (1.36) $ 0.72
Weighted average shares used in computing net income (loss) per share:      
Basic (in shares) 74,967 63,329 52,055
Diluted (in shares) 74,967 63,329 52,573