Annual report pursuant to Section 13 and 15(d)

STOCK-BASED COMPENSATION (Details)

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STOCK-BASED COMPENSATION (Details) (USD $)
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Stock-based compensation expense related to stock-based awards      
Total stock-based compensation expense $ 12,617,000 $ 13,168,000 $ 16,436,000
Research and development
     
Stock-based compensation expense related to stock-based awards      
Total stock-based compensation expense 7,050,000 9,277,000 9,025,000
General and administrative
     
Stock-based compensation expense related to stock-based awards      
Total stock-based compensation expense $ 5,567,000 $ 3,891,000 $ 7,411,000