Annual report pursuant to Section 13 and 15(d)

PROPERTY AND EQUIPMENT (Details)

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PROPERTY AND EQUIPMENT (Details) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
PROPERTY AND EQUIPMENT      
Total property and equipment $ 14,241,000 $ 13,153,000  
Less accumulated depreciation and amortization (12,854,000) (12,278,000)  
Property and equipment, net 1,387,000 875,000  
Assets disposed 18,000 7,000,000  
Depreciation and amortization 594,000 465,000 $ 941,000
Restructuring, asset impairment charges     $ 319,000
Laboratory equipment      
PROPERTY AND EQUIPMENT      
Total property and equipment 11,317,000 11,122,000  
Computer and software      
PROPERTY AND EQUIPMENT      
Total property and equipment 1,521,000 1,320,000  
Furniture and equipment      
PROPERTY AND EQUIPMENT      
Total property and equipment $ 1,403,000 $ 711,000