Annual report pursuant to Section 13 and 15(d)

STATEMENTS OF STOCKHOLDERS' EQUITY

v3.10.0.1
STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Common stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Total
Balance at Dec. 31, 2015 $ 91 $ 1,082,980 $ (44) $ (991,646) $ 91,381
Balance (in shares) at Dec. 31, 2015 90,554,589        
Increase (Decrease) in Stockholders' Equity          
Net loss       (69,216) (69,216)
Net change in unrealized gain or loss on short-term investments     26   26
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 1 1,597     1,598
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 819,266        
Issuance of common stock, net of offering costs $ 8 23,398     23,406
Issuance of common stock, net of offering costs (in shares) 7,895,563        
Stock compensation expense   7,832     7,832
Balance at Dec. 31, 2016 $ 100 1,115,807 (18) (1,060,862) 55,027
Balance (in shares) at Dec. 31, 2016 99,269,418        
Increase (Decrease) in Stockholders' Equity          
Net loss       (77,992) (77,992)
Net change in unrealized gain or loss on short-term investments     (64)   (64)
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 1 3,507     3,508
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 1,564,395        
Issuance of common stock, net of offering costs $ 46 114,134     114,180
Issuance of common stock, net of offering costs (in shares) 45,981,093        
Stock compensation expense   5,987     5,987
Balance at Dec. 31, 2017 $ 147 1,239,435 (82) (1,138,854) 100,646
Balance (in shares) at Dec. 31, 2017 146,814,906        
Increase (Decrease) in Stockholders' Equity          
Net loss       (70,480) (70,480)
Net change in unrealized gain or loss on short-term investments     58   58
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 2 4,730     4,732
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 1,956,599        
Issuance of common stock, net of offering costs $ 18 67,144     67,162
Issuance of common stock, net of offering costs (in shares) 18,400,000        
Stock compensation expense   7,759     7,759
Balance at Dec. 31, 2018 $ 167 $ 1,319,068 $ (24) $ (1,209,334) $ 109,877
Balance (in shares) at Dec. 31, 2018 167,171,505