Annual report pursuant to Section 13 and 15(d)

STATEMENTS OF STOCKHOLDERS' EQUITY

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STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Common stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Total
Balance at Dec. 31, 2014 $ 88 $ 1,068,347 $ (7) $ (940,182) $ 128,246
Balance (in shares) at Dec. 31, 2014 88,041,445        
Increase (Decrease) in Stockholders' Equity          
Net loss       (51,464) (51,464)
Net change in unrealized loss on short-term investments     (37)   (37)
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 1 1,760     1,761
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 790,832        
Issuance of common stock, net of offering costs $ 2 5,470     5,472
Issuance of common stock, net of offering costs (in shares) 1,722,312        
Stock compensation expense   7,403     7,403
Balance at Dec. 31, 2015 $ 91 1,082,980 (44) (991,646) 91,381
Balance (in shares) at Dec. 31, 2015 90,554,589        
Increase (Decrease) in Stockholders' Equity          
Net loss       (69,216) (69,216)
Net change in unrealized loss on short-term investments     26   26
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 1 1,597     1,598
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 819,266        
Issuance of common stock, net of offering costs $ 8 23,398     23,406
Issuance of common stock, net of offering costs (in shares) 7,895,563        
Stock compensation expense   7,832     7,832
Balance at Dec. 31, 2016 $ 100 1,115,807 (18) (1,060,862) 55,027
Balance (in shares) at Dec. 31, 2016 99,269,418        
Increase (Decrease) in Stockholders' Equity          
Net loss       (77,992) (77,992)
Net change in unrealized loss on short-term investments     (64)   (64)
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 1 3,507     3,508
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 1,564,395        
Issuance of common stock, net of offering costs $ 46 114,134     114,180
Issuance of common stock, net of offering costs (in shares) 45,981,093        
Stock compensation expense   5,987     5,987
Balance at Dec. 31, 2017 $ 147 $ 1,239,435 $ (82) $ (1,138,854) $ 100,646
Balance (in shares) at Dec. 31, 2017 146,814,906