Annual report pursuant to Section 13 and 15(d)

STOCK-BASED COMPENSATION (Details)

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STOCK-BASED COMPENSATION (Details) - USD ($)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Stock-based compensation expense related to stock-based awards      
Total stock-based compensation expense $ 5,987,000 $ 7,832,000 $ 7,403,000
Incremental stock-based compensation expense 1,400,000 1,100,000  
General and administrative      
Stock-based compensation expense related to stock-based awards      
Total stock-based compensation expense 4,490,000 4,230,000 3,303,000
Research and development      
Stock-based compensation expense related to stock-based awards      
Total stock-based compensation expense 1,497,000 3,103,000 $ 4,100,000
Restructuring charges      
Stock-based compensation expense related to stock-based awards      
Total stock-based compensation expense $ 499,000 $ 499,000