Annual report pursuant to Section 13 and 15(d)

INCOME TAXES (Tables)

v3.8.0.1
INCOME TAXES (Tables)
12 Months Ended
Dec. 31, 2017
INCOME TAXES  
Schedule of components of the entity's deferred tax assets

Significant components of our deferred tax assets are as follows (in thousands):

 

 

 

 

 

 

 

 

 

 

 

December 31,

 

 

    

2017

    

2016

 

Deferred tax assets

 

 

 

 

 

 

 

Net operating loss carryforwards

 

$

212,153

 

$

297,445

 

Orphan drug and research and development credits

 

 

51,744

 

 

44,348

 

Deferred compensation

 

 

12,261

 

 

21,618

 

Capitalized research and development expenses

 

 

4,690

 

 

1,877

 

Other, net

 

 

815

 

 

3,069

 

Total deferred tax assets

 

 

281,663

 

 

368,357

 

Valuation allowance

 

 

(281,663)

 

 

(368,357)

 

Net deferred tax assets

 

$

 —

 

$

 —

 

 

Schedule of reconciliation of the statutory federal income tax rate to the effective tax rate

 

 

 

 

 

 

 

 

 

 

Year Ended December 31,

 

 

    

2017

    

2016

    

2015

 

Federal statutory tax rate

 

(34.0)

%  

(34.0)

%  

(34.0)

%

Federal statutory rate reduction

 

160.2

%  

 —

 

 —

 

Valuation allowance

 

(126.5)

%  

35.0

%  

31.3

%

Stock compensation

 

5.7

%  

5.0

%  

8.3

%

Orphan drug and research and development credits

 

(3.6)

%  

(7.3)

%  

(5.6)

%

Other, net

 

(1.8)

%  

1.3

%  

 —

%  

Effective tax rate

 

0.0

%  

0.0

%  

0.0

%  

 

Schedule of activity related to the entity's gross unrecognized tax benefits

The following table summarizes the activity related to our gross unrecognized tax benefits (in thousands):

 

 

 

 

 

 

 

 

 

 

 

Year Ended December 31,

 

 

    

2017

    

2016

 

Balance at the beginning of the year

 

$

6,903

 

$

17,278

 

Increase related to prior year tax positions

 

 

 —

 

 

(11,332)

 

Increase related to current year tax positions

 

 

527

 

 

957

 

Balance at the end of the year

 

$

7,430

 

$

6,903